I’ve never given much thoughts to fine tuning string gauges for different tunings. Admittedly, this aspect of alternate tunings has to be addressed sooner or later in order to keep the guitar in good shape.

I found this article which covers basic points in regards to string gauges in an alternate tuning context:

http://www.bansheewerks.com/frivolities/geetar/tech.shtml#gauges

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