On a standard six string guitar, you can assign one of 12 tones to a string. Considering there are six strings, you have a possibility of 12 x 12 x 12 x 12 x 12 x 12 choices.
That’s 2 985 984 possible tunings.
If I were to explore all possible tunings, one each day, it would take me a little more than 8175 years. So I think this blog will carry me on for a little while yet 🙂